Smallpox arrives in the Americas
1518* · Event
First smallpox outbreaks devastate indigenous populations with no immunity; mortality often >50% within decades of contact.
On these timelines: Pre-Columbian Americas, Master, Pandemics & Plagues, USA, Conquest of the Aztec Empire
More from Pre-Columbian Americas
- Peopling of the Americas (14000 BCE)
- Maya civilisation (2000 BCE)
- Maize domesticated in Mesoamerica (7000 BCE)
- Olmec civilisation (1500 BCE)
- Teotihuacán at its peak (100)
- Inca expansion under Pachacuti (1438)
- Classic Maya civilization (250)
- Aztec Triple Alliance formed (1428)
Around 1518
- Magellan-Elcano circumnavigation (1519)
- English Reformation (1533)
- Columbus reaches the Americas (1492)
- Spanish conquest of the Aztec Empire (1519)
- Eighty Years' War / Dutch Revolt (1568)
- Spanish conquest of the Incas (1532)
- French Wars of Religion (1562)
- Spanish Reconquista last campaign (1482)
- The Reformation (1517)
- Luther's 95 Theses (1517)